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Endothelin‐1 plasma levels and hypertension in cyclosporine‐treated renal transplant patients
Author(s) -
Cauduro Rafael L,
Costa Cesar,
Lhulier Francisco,
Garcia Règis G,
Cabral Renan D,
Gonçalves Luiz FS,
Manfro Roberto C
Publication year - 2005
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2005.00357.x
Subject(s) - medicine , ingestion , blood pressure , endothelin receptor , creatinine , endothelin 1 , gastroenterology , population , renal function , transplantation , endocrinology , urology , receptor , environmental health
Abstract: Experimental models suggest that endothelin‐1 (ET‐1) has a significant role in the pathogenesis of cyclosporin A (CyA)‐induced hypertension. However, its serum levels evaluated in different studies, including patients who received solid organ transplants, exhibited controversial results. Our study population consisted of 43 renal transplant patients: 33 were taking CyA as a component of their immunosuppressive regimen (CyA group) and 10 that were not taking CyA (control group). Baseline laboratory data, blood pressure and ET‐1 levels were taken at baseline and 3 and 4 h after the ingestion of CyA. In the control group samples were collected in the corresponding periods of time. Blood pressure was significantly higher in the CyA group (mean blood pressure: 101.2 ± 9.5 vs. 91.1 ± 10.7 mmHg; p < 0.001), who also presented higher serum creatinine (1.2 ± 0.28 vs. 0.97 ± 0.13 mg/dL; p < 0.001) and ET‐1 levels. In the CyA group an ET‐1 peak was evident by the third hour after CyA ingestion that showed its maximum concentration after 1–2 h; the control group exhibited significantly lower levels of ET‐1 (p = 0.044). ET‐1 levels compared between patients with and without hypertension showed a non‐statistically significant difference (1.54 ± 0.76 vs. 1.27 ± 0.62 ng/mL; p = 0.27, respectively). In conclusion, in the present study chronic CyA ingestion was associated with higher blood pressure and plasma ET‐1 levels.