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Negative impact of ‘old‐to‐old’ donations on success of cadaveric renal transplants
Author(s) -
WeissSalz Inbal,
Mandel Micha,
Galai Noya,
Boner Geoffrey,
Mor Eytan,
Nakache Richard,
Simchen Elisheva
Publication year - 2005
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2005.00353.x
Subject(s) - medicine , cadaveric spasm , surgery , multivariate analysis , proportional hazards model , univariate analysis , renal transplant , univariate , transplantation , multivariate statistics , statistics , mathematics
The effect of ‘old‐to‐old’ cadaveric renal transplants on operative complications and graft survival was assessed in all 325 patients undergoing solitary cadaveric renal transplantations in Israel during a 3‐yr period. Preoperative information and hospital course data were abstracted from the charts. Results were analyzed using Kaplan–Meyer survival curves, univariate and multivariate Cox models. Overall, 62 (19.1%) grafts failed within a year. Failure rate was 46.2% for ‘old‐to‐old’ transplants compared with 15.5% for all other donor/recipient age combinations (p < 0.0001). ‘Old‐to‐old’ transplants remained independently associated with graft failure in a multivariate Cox model after controlling the effect of other risk factors. ‘Old‐to‐old’ transplants were also associated with increased operative complications relative to other age combinations. The decision to use ‘old‐to‐old’ transplants, even when donors are scarce, is problematic and should be reconsidered.