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Accelerated rejection following offspring‐to‐mother and husband‐to‐wife transplants
Author(s) -
Rosenberg Jerry C.,
Jones Bruce,
Oh Henry
Publication year - 2004
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2004.00250.x
Subject(s) - medicine , offspring , in utero , wife , pregnancy , sensitization , human leukocyte antigen , histocompatibility , fetus , immunology , antigen , obstetrics , genetics , political science , law , biology
It has been demonstrated that graft survival rates of offspring‐to‐mother and husband‐to‐wife renal transplants are equivalent to those of other living donors. Although the vast majority of these transplants proceed without incident, we have encountered several instances of delayed accelerated rejections that are not predicted by a positive cross‐match. The accelerated rejection can result from an anamnestic reaction subsequent to the in utero exposure of the mother to human leukocyte antigen (HLA) antigens of the fetus with sensitization developing during the pregnancy.