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ABO blood group influences a candidate's likelihood of receiving an HLA zero antigen mismatch kidney
Author(s) -
Bryan Christopher F,
Cherikh Wida S,
Cheng Yulin,
Aeder Mark I,
Muruve Nicolas A,
Nelson Paul W,
Shield Charles F,
Warady Bradley A,
Winklhofer Franz T
Publication year - 2004
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2004.00219.x
Subject(s) - medicine , abo blood group system , human leukocyte antigen , immunology , antigen , hla a
National sharing of HLA zero‐mismatched kidneys has improved long‐term graft survival. The distribution of those HLA‐matched kidneys by ABO blood group, however, has not been examined. Utilizing the UNOS/OPTN (United Network for Organ Sharing/Organ Procurement Transplantation Network) database, we analysed 112 971 kidney waiting list registrations added during 6/3/95–31/12/00, and 8162 HLA zero‐mismatched (0 mm) primary kidney transplants in the USA during 1/1/88–31/3/02. We also analyzed A isoagglutinin titer histories for 87 blood group B end stage renal disease (ESRD) patients for whom at least 1 yr of testing was done. Blood group A patients received 40.1% of the HLA‐0 mm kidneys while having a 26.5% representation on the national waiting list. Blood group B patients comprised 17.4% of the waiting list, but received only 10.4% of the HLA‐0 mm kidneys. Most (89.6%) blood group B patients awaiting kidney transplantation have low levels of A isoagglutinins, making them eligible to receive a blood group A 2 kidney transplant. The national HLA‐0 mm kidney allocation sharing system's imbalance by ABO blood group could be partially resolved in the future by allocating HLA‐0 mm blood group A 2 kidneys to B patients.