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Effect of combined T‐ and B‐cell depletion of allogeneic HLA‐mismatched bone marrow graft on the magnitude and kinetics of Epstein–Barr virus load in the peripheral blood of bone marrow transplant recipients
Author(s) -
Liu Daorong,
Tammik Charlotte,
Zou JieZhi,
Ernberg Ingemar,
Masucci Maria G.,
Ringden Olle,
Levitsky Victor
Publication year - 2004
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2004.00198.x
Subject(s) - medicine , immunology , bone marrow , human leukocyte antigen , epstein–barr virus , lymphoproliferative disorders , t cell , virus , herpesviridae , b cell , peripheral , antigen , antibody , lymphoma , viral disease , immune system
Recipients of T‐cell‐depleted bone marrow (BM) transplants (BMT) frequently develop Epstein–Barr virus (EBV)‐associated post‐transplant lymphoproliferative disease (PTLD) preceded by a rapid and prominent increase of EBV load in the peripheral blood. The level of this increase positively correlates with the incidence of PTLD. Using a semiquantitative PCR assay we compared the blood levels of EBV‐DNA in patients transplanted with either T‐cell or T‐ and B‐cell‐depleted human leukocyte antigen (HLA)‐mismatched BM grafts. Combined T‐ and B‐cell depletion correlated with significantly lower maximal levels of EBV load, which were reached with slower kinetics. These data indicate that B‐cell depletion of BM can be used for prophylaxis of PTLD in BM transplant recipients and can affect the long‐term balance between EBV and its host.