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Midline axon guidance and human genetic disorders
Author(s) -
Izzi L,
Charron F
Publication year - 2011
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.2011.01735.x
Subject(s) - axon guidance , neuroscience , biology , spinal cord , corpus callosum , axon , central nervous system , anatomy , biological neural network , nervous system , process (computing) , computer science , operating system
Izzi L, Charron F. Midline axon guidance and human genetic disorders. In bilaterally symmetric animals, many axons cross the midline to interconnect the left and right sides of the central nervous system (CNS). This process is critical for the establishment of neural circuits that control the proper integration of information perceived by the organism and the resulting response. While neurons at different levels of the CNS project axons across the midline, the molecules that regulate this process are common to many if not all midline‐crossing regions. This article reviews the molecules that function as guidance cues at the midline in the developing vertebrate spinal cord, cortico‐spinal tract and corpus callosum. As well, we describe the mutations that have been identified in humans that are linked to axon guidance and midline‐crossing defects.