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Thromboembolism and coumarin overdosage in a 19‐year‐old female: impact of pharmacogenetics
Author(s) -
Brenner C,
Huber B,
Becker A,
Ostermann H,
Becker C,
Steinbeck G,
Franz WM
Publication year - 2010
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.2010.01477.x
Subject(s) - medicine , cardiology , emergency medicine , nuclear medicine
To the Editor : Individualized therapies based on the patients’ unique pharmacogenomics and pharmacogenetics will become an all-important topic in various medical disciplines within the forthcoming years. The clinical case presented here underlines the need for future individualized and genotype-adapted medical treatment. Written consent to publish this report has been obtained from the patient. In 2009, a 19-year-old female patient was admitted from another hospital with bilateral pulmonary embolism as a result of deep venous thrombosis after an arthroscopy of the right talocalcaneal joint a few weeks ago. Under initiated phenprocoumon therapy with a cumulative dose of 16.5 mg over 3 days and overlapping administration of heparin