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Experts' opinions on ethical issues of genetic research into Alzheimer's disease: results of a Delphi study in the Netherlands
Author(s) -
Van Der Vorm A,
Van Der Laan AL,
Borm G,
VernooijDassen M,
Olde Rikkert M,
Van Leeuwen E,
Dekkers W
Publication year - 2010
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.2009.01323.x
Subject(s) - delphi method , ethical issues , bioethics , disease , dementia , medicine , psychology , family medicine , genetic testing , medical education , engineering ethics , political science , pathology , law , statistics , mathematics , engineering
van der Vorm A, van der Laan AL, Borm G, Vernooij‐Dassen M, Rikkert MO, van Leeuwen E, Dekkers W. Experts' opinions on ethical issues of genetic research into Alzheimer's disease: results of a Delphi study in the Netherlands. Most publications on the ethical aspects of genetic research into Alzheimer's Disease (AD) concentrate on the differences between the opinions of professionals and non‐professionals. Differences in rating of morally relevant issues between groups of professionals have not yet been described. A modified Delphi study in two rounds was held to identify differences between groups of experts (i.e. clinicians, representatives of patient organisations, ethicists and persons with a commercial background). The strongest correlation was found between the opinions of ethicists and representatives of patient organisations (0.67) and between clinicians and ethicists (0.62). Moderate correlation (0.55) was found between the opinions of clinicians and representatives of patient organisations. Persons with a commercial background showed a weak correlation with clinicians (0.41), ethicists (0.35) and representatives of patient organisations (0.30). These differences in rating of morally relevant issues between various professional groups are relevant for clinical practice and dementia care, particularly the different rating of prenatal diagnosis found between clinicians and representatives of patient organisations. Interdisciplinary consultations between various professional groups –including at least researchers, clinicians and ethicists –are recommended to guarantee that all considerations will be incorporated into the debate on ethical issues of genetic research into AD.