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Association of the CT gene (CA) polymorphism with BMD in osteoporotic mexican women
Author(s) -
Magaña JJ,
Gómez R,
Cisneros B,
Casas L,
Castorena F,
Miranda A,
Diez P,
Castro C,
Rubio J,
Valdés M
Publication year - 2006
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.2006.00703.x
Subject(s) - osteoporosis , odds ratio , medicine , allele , genotype , bone mineral , endocrinology , confidence interval , allele frequency , gastroenterology , genetics , biology , gene
Calcitonin (CT) plays a role in the pathogenesis of osteoporosis and genetic variations in or adjacent to the CT gene may be associated with loss of bone mineral density (BMD). The correlation between a dinucleotide (cytosine–adenine) repeat polymorphism at the CT locus and BMD was examined in 70 osteoporotic women, 70 non‐osteoporotic women and 500 subjects from the Mexican population. The allele A and genotype AA frequencies were significantly higher in osteoporotic women than in non‐osteoporotic women (60% vs 32%; p < 0.0001 and 41% vs 14%; p = 0.0007, respectively). Genotype AA was associated with the presence of osteoporosis [odds ratio 2.58; 95% confidence interval (CI); 1.62–4.12]. Likewise, the loss of lumbar BMD and T scores were related to the presence of allele A: subjects with a single A allele displayed lower values for lumbar BMD and T score (84.02% and −1.51, respectively) than those who do not present any A allele (89.61% and −0.88, respectively). Individuals with two alleles A showed the lowest lumbar BMD and T‐score values (73.77% and −2.51, respectively). Analysis of potential confounder demonstrated that aging has a significant effect on osteoporosis development (odds ratio 1.1; 95% CI; 1.1052–1.152).