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Association of lipoprotein lipase S447X, apolipoprotein E exon 4, and apoC3 −455T>C polymorphisms on the susceptibility to diabetic nephropathy
Author(s) -
Ng MCY,
Baum L,
So WY,
Lam VKL,
Wang Y,
Poon E,
Tomlinson B,
Cheng S,
Lindpaintner K,
Chan JCN
Publication year - 2006
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.2006.00628.x
Subject(s) - lipoprotein lipase , medicine , endocrinology , apolipoprotein e , genotype , diabetic nephropathy , nephropathy , odds ratio , diabetes mellitus , chemistry , biology , genetics , disease , gene , adipose tissue
Diabetic nephropathy (DN) is the leading cause of end‐stage renal disease. In DN patients, triglyceride (TG) level is elevated and lipoprotein lipase (LPL) activity, which hydrolyzes TG, is decreased. The LPL S447X and apolipoprotein E ( APOE ) exon 4 polymorphisms affect TG levels, and the APOC3 −455T>C polymorphism affects LPL activity. Our aim was to examine the association of these polymorphisms with nephropathy in type 2 diabetes. We examined these polymorphisms in a case‐control study of type 2 diabetic patients including 374 with DN and 392 without DN. LPL 447X‐containing genotypes (447X+) were significantly decreased in DN patients [18.6 vs 25.6%, odds ratio (OR) = 0.66, p = 0.02], as were APOE ɛ3/ɛ3 genotypes (64.8 vs 73.1%, OR = 0.68, p = 0.01). In addition, combinations of genotypes [ APOE ɛ3/ɛ3 and LPL 447X+ (OR = 0.56), APOC3 CC and LPL 447X+ (OR = 0.31), APOE ɛ3/ɛ3 and APOC3 CC (OR = 0.61] were protective for DN compared with the most common combination of the respective polymorphisms. Our findings suggest the importance of interactions among lipid genes in modulating the risk of DN.