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Rare SP‐A alleles and the SP‐A1‐6A 4 allele associate with risk for lung carcinoma
Author(s) -
Seifart C,
Lin HM,
Seifart U,
Plagens A,
DiAngelo S,
Von Wichert P,
Floros J
Publication year - 2005
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.2005.00470.x
Subject(s) - lung cancer , allele , population , adenocarcinoma , medicine , oncology , lung cancer susceptibility , case control study , biology , genetics , gastroenterology , genotype , cancer , gene , single nucleotide polymorphism , environmental health
Next to cigarette smoking, genetic factors may contribute to lung cancer risk. Pulmonary surfactant components may mediate response to inhaled carcinogenic substances and/or play a role in lung function and inflammation. We studied associations between surfactant protein (SP) genetic variants and risk in lung cancer subgroups. Samples (n = 308) were genotyped for SP‐A1, ‐A2, ‐B, and ‐D marker alleles. These included 99 patients with small cell lung carcinoma (SCLC, n = 31), or non‐SCLC (NSCLC, n = 68) consisting of squamous cell carcinoma (SCC, n = 35), and adenocarcinoma (AC) (n = 23); controls (n = 99) matched by age, sex, and smoking status (clinical control) to SCLC and NSCLC; and 110 healthy individuals (population control). We found (a) no significant marker associations with SCLC, (b) rare SP‐A2 (1A 9 ) and SP‐A1 (6A 11 ) alleles associate with NSCLC risk when compared with population control, (c) the same alleles (1A 9 , 6A 11 ) associate with risk for AC when compared with population (6A 11 ) or clinical control (1A 9 ), and (d) the SP‐A1‐6A 4 allele (found in approximately 10% of the population) associates with SCC, when compared with population or clinical control. A correlation between SP‐A variants and lung cancer susceptibility appears to exist, indicating that SP‐A alleles may be useful markers of lung cancer risk.