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A polymorphism in the apolipoprotein A5 gene is associated with weight loss after short‐term diet
Author(s) -
Aberle J,
Evans D,
Beil FU,
Seedorf U
Publication year - 2005
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.2005.00463.x
Subject(s) - medicine , endocrinology , apolipoprotein b , body mass index , biology , overweight , triglyceride , allele , cholesterol , single nucleotide polymorphism , genetics , genotype , gene
Apolipoprotein A5 is a recently discovered apolipoprotein involved primarily in triglyceride metabolism. Several single‐nucleotide polymorphisms have been investigated since the initial report. The −1131T > C polymorphism has been associated with higher triglyceride levels and a decreased high‐density lipoprotein cholesterol as well as with susceptibility to coronary heart disease. However, no study has so far emphasized on the association of a dietary intervention with apolipoprotein A5 polymorphisms. In a group of 606 hyperlipaemic and overweight men, we investigated how a short‐term fat restriction affects lipid traits and body mass index (BMI) in wildtype and carriers of the −1131T > C polymorphism. Our result was that the reduction of BMI was significantly higher in C allele carriers (p = 0.0021). Since the −1131T > C polymorphism predisposes to coronary heart disease, a restriction diet is an important therapeutic approach in −1131T > C carriers.