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Genetic analysis of lethal congenital malformations causing perinatal mortality at Nizwa Hospital, Oman
Author(s) -
Sawardekar KP
Publication year - 2004
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.2004.00293.x
Subject(s) - consanguinity , medicine , congenital malformations , perinatal mortality , pediatrics , multifactorial inheritance , population , infant mortality , obstetrics , pregnancy , fetus , environmental health , biology , genetics , gene , genotype , single nucleotide polymorphism
An analysis of lethal congenital malformations (LCM) – which contributed to perinatal mortality at Nizwa Hospital, Oman – is presented for a 10‐year period from January 1993 through December 2002. Single gene, chromosomal or multifactorial inheritance accounted for 86.1% of the cases. LCM‐related perinatal deaths were higher in Omani, compared to those in non‐Omani births (p < 0.001). This could possibly be attributed to high consanguinity, low female literacy and high fertility rates in the Omani population. Forty per cent of LCM‐related perinatal deaths in the study had potential options for prevention. Integration of a community‐based genetic service into the existing health‐care delivery system is suggested.