Premium
Genetic variation in paraoxonase‐2 is associated with variation in plasma lipoproteins in Canadian Oji‐Cree
Author(s) -
Hegele Robert A,
Harris Stewart B,
Connelly Philip W,
Hanley Anthony JG,
Tsui LapChee,
Zinman Bernard,
Scherer Stephen W
Publication year - 1998
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1998.tb03752.x
Subject(s) - genetic variation , apolipoprotein b , paraoxonase , biology , genetics , variation (astronomy) , allele , lipoprotein , genotype , plasma lipoprotein , cholesterol , endocrinology , medicine , gene , oxidative stress , physics , astrophysics
We report studies of the association between genetic variation in PON2 and variation in plasma quantitative traits in a sample of 334 non‐diabetic Oji‐Cree. We detected associations between PON2 variation in codon 148 (Ala → Gly) and variation in fasting plasma concentrations of total and low‐density lipoprotein (LDL) cholesterol and apolipoprotein (apo) B. In particular, homozygotes for a PON2 allele that encoded A148 had significantly higher plasma total, LDL cholesterol and apo B than subjects having the other two genotypes (p <0.01). Taken together, our results suggest that common genetic variation on chromosome 7q21.3–22.1 in PON2 is associated with significant variation of intermediate traits in plasma lipoprotein metabolism.