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Apolipoprotein E genotypes in offspring with a positive and negative family history of premature myocardial infarction
Author(s) -
Rašlová Katarina,
Smolková Božena,
Vohnout Branislav,
Schifferdecker Branislav,
Poledne Rudolf,
Dusinšká Maria
Publication year - 1998
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1998.tb02751.x
Subject(s) - offspring , medicine , endocrinology , genotype , allele , apolipoprotein e , myocardial infarction , biology , triglyceride , apolipoprotein b , cholesterol , genetics , pregnancy , gene , disease
Apolipoprotein E (apo‐E) aliele and genotype frequencies were evaluated in offspring with positive (MI‐offspring) and negative (control‐offspring) parental history of myocardial infarction (MI). The apo‐E allele frequencies in MI‐and control‐offspring were as follows: ε2: 9.04 and 2.08% (p < 0.02), ε3: 84.04 and 87.5%. ε4: 6.91 and 10.41%, respectively. The frequencies of the E2‐genotypes were significantly lower in offspring of controls (4.2%, 17.0%, respectively, p < 0.03). The ε2‐allele is associated with raised plasma triglyceride concentrations in subjects on a diet high in saturated fat. We therefore hypothesize that offspring carrying an ε2‐allele are predisposed to develop disturbance of plasma triglyceride metabolism when exposed to a traditional Slovak high‐fat diet and/or weight gain, resulting in altered lipid levels and increased predisposition to atherosclerosis.