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Photoanthropometric study of craniofacial traits in individuals with Prader‐Willi syndrome on short‐term growth hormone therapy
Author(s) -
Butler Merlin G,
Hovis Christopher L,
Angulo Moris A
Publication year - 1998
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1998.tb02694.x
Subject(s) - chin , craniofacial , medicine , palpebral fissure , growth hormone , growth hormone deficiency , pediatrics , hormone , surgery , anatomy , psychiatry
An objective photoanthropometric method, useful for delineating craniofacial characteristics, was performed on 20 individuals with Prader‐Willi syndrome (PWS; 14 males and 6 females) under 12 years of age and on growth hormone therapy (e.g. for 3–12 months) to determine the effects of therapy on craniofacial features in PWS. Facial parameters were measured from strict frontal and profile photographic 35 mm slides and compared with other facial measurements from the same face (e.g. palpebral fissure width to bizygomatic diameter). We studied 16 photoanthropometric craniofacial indices following previously established protocols. Our photoanthropometric data on 20 PWS subjects meeting diagnostic criteria further supported previous findings of a high midface, a broad interalar distance, a prominent high chin and broad ears in PWS patients without growth hormone therapy. In addition, while on growth hormone therapy, the high midface, broad interalar distance and prominent high chin appeared to accentuate over time in relationship to untreated PWS patients. Conversely, broad appearing ears were not accentuated by growth hormone therapy in the PWS subjects analyzed in this study.