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Sex ratio and absence of uniparental disomy in spontaneous abortions with a normal karyotype
Author(s) -
Smith Martin J,
Creasy Michael R,
Clarke Angus,
Upadhyaya Meena
Publication year - 1998
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1998.tb02692.x
Subject(s) - autosome , karyotype , genetics , biology , uniparental disomy , chromosome , sex ratio , medicine , population , gene , environmental health
A series of spontaneous abortions collected in the South Wales region over a period of 18 months was karyotyped to identify those with a normal chromosome complement. Microsatellite polymorphisms distributed throughout all autosomes were typed by the polymerase chain reaction to determine the parental origin of each autosome pair in karyotypically normal spontaneous abortions. In 35 cases biparental inheritance of every autosome pair was demonstrated. The sex ratio of the normal spontaneous abortions of proven biparental origin was 0.77, but this was not significantly different from 1.00.