Premium
Detection of factor V Leiden mutation in severe pre‐eclamptic Hungarian women
Author(s) -
Nagy Bálint,
Tóth Tamás,
Jr János Rigó,
Karádi István,
Romics László,
Papp Zoltán
Publication year - 1998
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1998.tb02599.x
Subject(s) - mutation , genetics , medicine , factor v leiden , factor (programming language) , biology , gene , computer science , thrombosis , programming language , venous thrombosis
Pre‐eclampsia is a pregnancy‐related disorder that complicates approximately 5% of all pregnancies and is cited as the primary cause of worldwide maternal and fetal mortality. The factor V Leiden mutation has been implicated in the development of severe pre‐eclampsia. In order to investigate this association, a sample of 198 Hungarian women was recruited and enrolled in one of the three groups based on reproductive and health status: those as classified as pregnant and healthy (n = 71), those diagnosed as pregnant and severe pre‐eclamptic (n = 69), and those found to be healthy and non‐pregnant (n = 58). The presence of factor V Leiden mutation was determined by using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism analysis (RFLP). We identified three (5.2%) heterozygous among healthy non‐pregnant participants, five (7.0%) heterozygous among healthy pregnant participants and 13 (18.8%) heterozygous among preeclamptic women (p < 0.05, 95% CI). Our result supports the previous observation that carriers of factor V Leiden mutation are at increased risk for developing severe pre‐eclampsia.