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Association between asthma and an intragenic variant of CC16 on chromosome 11q13
Author(s) -
Mao XQ,
Shirakawa T.,
Kawai M.,
Enomoto T.,
Sasaki S.,
Dake Y.,
Kitano H.,
Hagihara A.,
Hopkin JM,
Morimoto K.
Publication year - 1998
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1998.tb02582.x
Subject(s) - atopy , locus (genetics) , asthma , biology , genetics , immunoglobulin e , chromosome , atopic dermatitis , gene , immunology , antibody
The β subunit of high affinity immunoglobulin E (IgE) receptor (FceRIβ) and the Clara cell derived inflammatory molecule, CC16 have been cited as candidate genes for atopic asthma on chromosome 11q13. A genetic association study was performed with an intragenic microsatellite repeat of CC16 gene on chromosome 11q12–13 in relation to atopic and non‐atopic asthma. Whereas variants of FceRIβ at chromosome 11q13 show association with atopy and asthma, no significant association was found between asthma and CC16 genotypes irrespective of atopic status. These data support the candidacy of FcsRIβ rather than CC16 for the atopic asthma locus on chromosome 11q.