Premium
Schizophrenia genetics at the millennium: cautious optimism
Author(s) -
Gottesman Irving I.,
Moldin Steven O.
Publication year - 1997
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1997.tb04361.x
Subject(s) - schizophrenia (object oriented programming) , genetic epidemiology , optimism , government (linguistics) , disease , biology , genetics , psychology , psychiatry , medicine , gene , social psychology , pathology , linguistics , philosophy
The views expressed here are the personal opinions of the authors and should not be taken to imply agreement or endorsement by the National Institutes of Health or the Federal Government. As the new millennium approaches, research into the genetic aspects of schizophrenia has already made an impressive start toward an integrated model which is discovering roles for genetic agents, environmental agents and experiences, and chance factors. The best model follows that proposed for understanding such complex diseases as coronary artery disease and diabetes. Genetic information has come from both genetic epidemiology and molecular genetics. Evidence for gene regions on 6p and 8p gives the strongest support for harboring schizophrenia susceptibility genes, based on international collaborative studies that “generally” replicate one another; evidence for regions on 3p, 5q, 9p, 20p, and 22q, while less compelling, will encourage focused work. Determining the steps between the regions and the phenotype will challenge the next generation of scientists.