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Analysis of the (CAG)n repeat causing Huntington's disease in a Mexican population
Author(s) -
Alonso Ma Elisa,
Yescas Petra,
Cisneros Bulmaro,
Martínez Claudia,
Silva Guadalupe,
Ochoa Adriana,
Montañez Cecilia
Publication year - 1997
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1997.tb02459.x
Subject(s) - allele , genetics , biology , huntington's disease , population , trinucleotide repeat expansion , allele frequency , gene , disease , medicine , environmental health
We investigated the allele distribution of the polymorphic (CAG)n repeat in the IT15 gene in 96 normal subjects from the Mexican population and 83 unrelated patients with Huntington's disease. Our results show that the size distributions of normal and affected alleles do not overlap. Normal alleles range from 13 to 32 triplets, with 18 being the most frequent allele, while HD alleles contain 37 to 76 repeats with 42 being the most frequent. One allele in the range of intermediate alleles was found (32 repeats) in a normal subject. The juvenile onset cases in this study are associated with an expansion greater than 49 repeats. In the available parent‐offspring pairs, paternal alleles show instability with an expansion of 28 repeats in one case.