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Genetic variation of the angiotensin‐converting enzyme gene: increased frequency of the insertion allele in Koreans
Author(s) -
Hong S. H.,
Kang B. Y.,
Park W. H.,
Kim J. Q.,
Lee C. C.
Publication year - 1997
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1997.tb02411.x
Subject(s) - genotype , angiotensin converting enzyme , allele , allele frequency , medicine , polymorphism (computer science) , coronary artery disease , body mass index , polymerase chain reaction , endocrinology , genotype frequency , genetics , biology , gene , blood pressure
In view of the clinical importance of angiotensin‐converting enzyme (ACE) as a major marker for cardiovascular diseases, we investigated insertion/deletion ( I/D ) polymorphism of the ACE gene in Koreans. Genotype frequencies were examined by polymerase chain reaction in 171 patients with coronary artery disease (CAD) and 120 healthy subjects. Allele frequencies of ACE polymorphism in Koreans were not significantly different between patient and control groups. In addition, association between ACE genotypes and the number of stenosed coronary arteries was not detected. ACE genotypes in the CAD group were not associated with body mass index and plasma lipid levels. Thus, our results suggest that, at least in Koreans, I/D polymorphism of the gene is unlikely to be a useful marker for CAD subjects. However, the I allele frequency of Koreans (0.58) was higher than that of Caucasian populations (0.47) but lower than that of Samoan (0.91) and Yanomami (0.85) populations. Here, we discuss the clinical and ethnic importance of ACE polymorphism.