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Population variation at the polymorphic ApaLI restriction enzyme site in intron 5 of the WT1 gene
Author(s) -
BesnardGuérin Corinne,
Winqvist Robert,
Newsham Irene,
Cavenee Webster K.
Publication year - 1996
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1996.tb02738.x
Subject(s) - loss of heterozygosity , genetics , allele , biology , locus (genetics) , intron , allele frequency , population , genotype , gene , medicine , environmental health
We examined 63 unrelated individuals from the United States for the ApaLI polymorphism in intron 5 of the WT1 gene. Allele frequencies of 0.13 and 0.87 for the A and B alleles, respectively, and a heterozygosity index of 24% contrast sharply with previous data obtained in the Japanese population where allele frequencies of 0.55 and 0.45 for the A and B alleles and a heterozygosity index of 59% were reported. These data suggest genetic heterogeneity at the WT1 locus, which may contribute to the differences in the incidence of Wilms tumor between the two population groups.