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Lack of association of angiotensin I‐converting enzyme gene polymorphism and premature myocardial infarction in Mauritian Indians
Author(s) -
Ramasawmy Rajendranath,
Manraj Meera,
Kotea Navaratnam,
Shun Nathalie Kok,
Genin Emmanuelle,
Feingold Josué,
Krishnamoorthy Rajagopal,
Baligadoo Sooriahnarain
Publication year - 1996
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1996.tb02737.x
Subject(s) - myocardial infarction , angiotensin converting enzyme , medicine , allele , renin–angiotensin system , polymorphism (computer science) , endocrinology , gene , genotype , allele frequency , biology , genetics , blood pressure
Eighty‐five young Mauritian Indians, male survivors of premature myocardial infarction (MI) and thus belonging to a high risk group, were compared with 108 stringently selected controls for a possible association between premature MI and an insertion/deletion (I/D) polymorphism in the gene encoding angiotensin I‐converting enzyme (ACE). The frequency of the D allele was 0.42 in the MI group and 0.43 in the control group, and thus no association between I/D polymorphism of ACE with susceptibility to early‐onset MI was found in this population group. Other gene components of the renin‐angiotensin system and lipid metabolism need to be explored to understand the genetic factors involved in causing MI at an early age.