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Increased paternal age in CHARGE association
Author(s) -
Tellier A.L.,
Lyonnet S.,
CormierDaire V.,
Lonlay P.,
Abadie V.,
Baumann C.,
Bonneau D.,
Labrune Ph.,
Lacombe D.,
Merrer M. Le,
Nivelon A.,
Philip N.,
Briard M. L.,
Munnich A.
Publication year - 1996
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1996.tb02736.x
Subject(s) - association (psychology) , genetics , medicine , biology , psychology , psychotherapist
The acronym CHARGE refers to a non‐random clustering of congenital malformations whose cause remains unknown. Here, we report on a series of 41 patients and find a significant increase in mean paternal age of birth of CHARGE patients (33.7±8 years) compared with the control population (30.8±5 years). In contrast, maternal age was not statistically different in patients and controls. These data suggest the possible role of a dominant mutation or, less likely, a subtle chromosomal abnormality in CHARGE association.