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High levels of Lp(a) lipoprotein in a family ith cases of severe pre‐eclampsia
Author(s) -
Husby Henrik,
Roald Borghild,
Schjetlein Rune,
Nesheim BrittIgjerd,
Berg Kåre
Publication year - 1996
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1996.tb02345.x
Subject(s) - lipoprotein(a) , lipoprotein , eclampsia , medicine , apolipoprotein b , endocrinology , pathogenesis , pregnancy , biology , cholesterol , genetics
We report a family with two cases of severe pre‐eclampsia/eclampsia in which very high levels of Lp(a) lipoprotein were found. The serum level of Lp(a) lipoprotein is genetically determined and the Lp(a) apolipoprotein has a close homology to plasminogen. Very high levels of Lp(a) lipoprotein might interfere with the fibrinolytic/thrombolytic process in man. A previous report suggested that a high maternal serum Lp(a) lipoprotein level can cause fetal growth retardation, and it is proposed that very high levels might lead to increased deposition of fibrin in the uterine spiral arteries in pregnancy, which is central in the pathogenesis of pre‐eclampsia. If confirmed, a very high Lp(a) lipoprotein level could be one risk factor for pre‐eclampsia that is genetically determined.