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Heredity in dementia of the Alzheimer type
Author(s) -
Bergem A. L. Mina
Publication year - 1994
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1994.tb04216.x
Subject(s) - heredity , disease , dementia , alzheimer's disease , twin study , medicine , linkage (software) , genetics , psychology , biology , pathology , heritability , gene
Family, twin and linkage studies in Alzheimer's disease are reviewed. Several of these studies appear to be burdened with sources of error, mainly related to sampling and clinical diagnoses. It was previously thought that early‐onset cases of Alzheimer's disease were heavily genetically influenced, whereas late‐onset cases were sporadic. The author questions whether this difference is mainly due to methodological error.