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Down syndrome and male fertility: PCR‐derived fingerprinting, serological and andrological investigations
Author(s) -
Zühlke Christine,
Thies Ulrike,
Braulke Ingrid,
Reis André,
Schirren Carl
Publication year - 1994
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1994.tb04171.x
Subject(s) - minisatellite , sterility , biology , offspring , genetics , trisomy , serology , dna profiling , phenotype , male infertility , klinefelter syndrome , infertility , microsatellite , dna , pregnancy , allele , endocrinology , gene , antibody
Down syndrome, the most common birth defect causing mental retardation, is characterized by a specific phenotype including subfertility or sterility and hypogonadism in males. In contrast, several females with Down syndrome have borne offspring. Here, a male with trisomy 21 fathering an infant is described. This observation is verified by serological markers, DNA fingerprinting using different DNA micro‐or minisatellites and andrological investigations.