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Inbreeding and congenital heart diseases in a North Indian population
Author(s) -
Afzal Mohd.
Publication year - 1994
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1994.tb04032.x
Subject(s) - offspring , cousin , consanguinity , inbreeding , demography , consanguineous marriage , endogamy , population , incidence (geometry) , medicine , genetics , biology , pediatrics , pregnancy , geography , physics , archaeology , sociology , optics
The study was performed in six mohallahs (colonies) of Aligarh City (North India). All six mohallahs are predominantly inhabited by Qureshi (meat sellers, a highly endogamous group) Muslims. A total of 1721 infants and children up to the age of 6 years were examined to determine the incidence of congenital heart diseases (CHD) in relation to the degree of consanguinity of the parents. Around 43% of the subjects were the offspring of consanguineous marriages including second‐cousin, first‐cousin‐once‐removed and first‐cousin. A higher percentage of CUD was found in the offspring of consanguineous marriages: about 3.37% out of 741 children as compared to 1.22% in 980 offspring of non‐consanguineous marriages, whereas in the first‐cousin offspring, the percentage of CHD rose to 4.41%. The differences were found to be statistically significant. The present study suggests a genetic influence and also casts doubt on the applicability of a polygenic threshold model to all forms of cardiac malformation.