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No effect of insertion/ deletion polymorphism at the ACE locus on normal blood pressure level or variability
Author(s) -
Berge K. E.,
Berg K.
Publication year - 1994
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1994.tb04017.x
Subject(s) - blood pressure , locus (genetics) , genotype , insertion , angiotensin converting enzyme , renin–angiotensin system , genetics , medicine , biology , endocrinology , angiotensin ii , gene , mutation
Angiotensin I‐converting enzyme (ACE) cleaves angiotensin I to angiotensin II, which is the active component in the renin‐angiotensin system (RAS). We have studied an insertion/deletion polymorphism in DNA at the ACE locus. In three different series comprising 140, 90 and 136 unrelated individuals we found no evidence of association between genotypes in this insertion/deletion (I/D) polymorphism and level of systolic or diastolic blood pressure. In two series of 130 and 88 monozygotic (MZ) twin pairs, respectively, there was no difference between genotypes in within‐pair variation in systolic or diastolic blood pressure. Thus, in these series of healthy people, neither “level gene” nor “variability gene” effects of this insertion/deletion polymorphism were observed.