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Chromosome instability in lymphocytes from patients with celiac disease
Author(s) -
Fundia A. F.,
Cid M. B. González,
Bai J.,
Gómez J. C.,
Mazure R.,
Vazquez K.,
Larripa I. B.,
Slavutsky I. R.
Publication year - 1994
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1994.tb03994.x
Subject(s) - chromosome instability , chromosome , sister chromatid exchange , genome instability , sister chromatids , breakpoint , chromatid , karyotype , lymphocyte , biology , medicine , incidence (geometry) , genetics , gastroenterology , endocrinology , dna damage , dna , physics , gene , optics
Cytogenetic studies were performed in celiac disease (CD) patients to determine if the presence of chromosome instability is related to the predisposition to cancer. Chromosome aberrations (CA) and sister chromatid exchange (SCE) frequencies in peripheral blood lymphocyte cultures from untreated CD patients and healthy controls were analyzed. Patients showed aberrations in 23% of cells, while only 3% were detected in the control group (p < 0.0001). The mean frequencies of gaps, breaks and total CA were found to be higher in CD patients compared to controls (p < 0.0001). Breakpoint distribution was nonrandom among chromosomes from celiac patients (p = 0.01), but not among controls (p = 0.04). The frequency of SCE/cell showed a mean value of 6.9 ± 0.6 in CD patients and 7.3 ± 0.2 in controls. No statistical differences were found. Breakpoints involved in CD patients presented a strong coincidence with the location of fragile sites (78.6%) and sites of cancer chromosome rearrangements (57.1%), most of them (75%) associated with malignant non‐Hodgkin lymphomas. These results suggest that CD is a condition with increased chromosome instability characterized by a high level of CA and normal SCE frequencies, probably related to the increased incidence of cancer.