Premium
Prenatal detection of cri du chat syndrome on uncultured amniocytes using fluorescence in situ hybridization (FISH)
Author(s) -
Pettenati Mark J.,
Hayworth Rosa,
Cox Kelly,
Rao P. Nagesh
Publication year - 1994
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1994.tb03983.x
Subject(s) - fluorescence in situ hybridization , in situ hybridization , fish <actinopterygii> , cytogenetics , biology , microbiology and biotechnology , in situ , interphase , prenatal diagnosis , chromosome , karyotype , hybridization probe , molecular cytogenetics , genetics , dna , fetus , chemistry , pregnancy , gene , fishery , gene expression , organic chemistry
Fluorescence in situ hybridization (FISH) with a chromosome‐region‐specific DNA probe was used prospectively on uncultured amniocyte interphase cells to detect an unbalanced chromosome abnormality that resulted in cri du chat or 5p – syndrome. Confirmation was performed by routine cytogenetics.