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Normal genetic variation at the low density lipoprotein receptor (LDLR) locus influences cholesterol levels in children
Author(s) -
Poledne Rudolf,
Pisa Zbynek,
Berg Kåre
Publication year - 1993
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1993.tb04435.x
Subject(s) - ldl receptor , locus (genetics) , cholesterol , medicine , biology , endocrinology , population , restriction fragment length polymorphism , lipoprotein , genetic variation , genetics , familial hypercholesterolemia , low density lipoprotein , gene , genotype , environmental health
The population of Czechoslovakia is at high risk of premature atherosclerosis. Normal DNA polymorphism at the low density lipoprotein receptor (LDLR) locus detectable with the restriction enzyme PvuII was analyzed in Czech children with a high or a low concentration of total serum cholesterol. The PvuII restriction site was found significantly more often in the low cholesterol group than in the high cholesterol group. Thus, normal genetic variation at the LDLR locus contributes to the population variation in cholesterol in children in the population studied.