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Multipoint linkage analysis in X‐linked juvenile retinosclusis
Author(s) -
Bergen A. A. B.,
Schooneveld M. J.,
Orth U.,
BleekerWagemakers E. M.,
Gal A.
Publication year - 1993
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1993.tb04433.x
Subject(s) - locus (genetics) , linkage (software) , genetic linkage , genetics , biology , lod score , x chromosome , gene mapping , chromosome , gene
Thirteen families with X‐linked juvenile retinoschisis (XLRS) were studied in order to evaluate the linkage relationship between the XLRS locus (RS) and seven X‐chromosomal DNA markers. Linkage was found between RS and DXS9 ( max = O.11, Z max = 4.17), DXS16 (θ max = 0.06, Z max = 7.72), DXS41 (θ max = 0.06, Z max = 8.13) and DXS43 (θ max = 0.03, Z max = 6.11). Recombinants were found between RS and all loci studied. Multipoint linkage analysis and recombination analysis significantly favour the order of Xpter‐(DXS9, (DXS16‐DXS43))‐RS‐DXS41 ‐Xcen.