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The hand‐foot‐genital syndrome: on the variable expression in affected males
Author(s) -
Fryns J. P.,
Vogels A.,
Decock P.,
Berghe H.
Publication year - 1993
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1993.tb03808.x
Subject(s) - hypospadias , sex organ , variable expression , foot (prosody) , mentally retarded , medicine , sibling , biology , anatomy , psychology , developmental psychology , genetics , linguistics , philosophy , gene
Fryns JP, Vogels A, Decock P, Van den Berghe H. The hand‐foot‐genital syndrome: on the variable expression in affected males. Clin Genet 1993: 43: 232–234. © Munksgaard, 1993 In this report we document male‐to‐male transmission in the hand‐foot‐genital syndrome. An affected father transmitted the syndrome to his three sons. A grade IV hypospadias, which was the most severe genital anomaly in affected males, was present in the youngest, moderately mentally retarded microcephalic male sibling.