Premium
Quality control in routine chromosome analysis: prediction of total number of bands for the individual case analyzed
Author(s) -
Claussan U.,
Kleider W.,
Muller H.G.,
Wills N.,
Baumann H. A.
Publication year - 1992
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1992.tb03642.x
Subject(s) - chromosome , karyotype , metaphase , ploidy , linear regression , genetics , biology , mathematics , statistics , gene
Claussen U, Kleider W, Müller H‐G, Wille N, Baumann HA. Quality control in routine chromosome analysis: prediction of total number of bands for the individual case analyzed. Clin Genet 1992: 41: 100–104. In routine diagnosis it is of importance for each single analysis to provide information about the level of quality at which the chromosomal analysis has been performed. The number of bands counted can be used as a direct criterion for the level of quality. Statistical prediction methods via linear regression were employed in order to predict the total number of bands of a haploid set of the metaphase (TNB) from those of single chromosomes or pairs of chromosomes. It was demonstrated that TNB can be predicted successfully by counting bands on just one chromosome, where chromosomes C2, C4, C5 or C7 were found suitable for prediction. If pairs of chromosomes are used to predict TNB, we would recommend C4/C7, C5/C6, and C2/C9.