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Estimates of heritability of plasma homocyst(e)ine levels in aging adult male twins
Author(s) -
Reed Terry,
Malinow M. Rene,
Christian Joe C.,
Upson Barbara
Publication year - 1991
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1991.tb03053.x
Subject(s) - endocrinology , medicine , intraclass correlation , heritability , chemistry , biology , genetics , reproducibility , chromatography
Plasma homocyst(e)ine level was determined for 96 identical (MZ) and 92 fraternal (DZ) adult male twins aged 59–69. There was no difference in mean between MZ (10.31 nmol/ml) and DZ (10.36 nmol/ml) twins. The intraclass correlation coefficient of the log‐transformed homocyst(e)ine level in 43 complete MZ and 39 complete DZ pairs was 0.55 and 0.19, respectively. The MZ correlation was significantly (p<0.05) greater than the DZ correlation, suggesting that the level of plasma homocyst(e)ine is genetically influenced.