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Transcobalamins in the etiology of neural tube defects
Author(s) -
Magnus Per,
Magnus Erik M.,
Berg Kåre
Publication year - 1991
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1991.tb03032.x
Subject(s) - neural tube , etiology , offspring , amniotic fluid , pregnancy , medicine , neural tube defect , anencephaly , physiology , endocrinology , biology , genetics , fetus , embryo
In a sample of 79 pregnant women at risk of having offspring with neural tube defects (NTDs) and 158 controls, significantly increased median values were found for apo‐transcobalamins I and II in amniotic fluid in the group at risk, thus confirming previous results. The findings may reflect a genetic disposition to NTDs associated with altered levels of apo‐transcobalamins, and research on the etiology and mechanisms of NTDs should focus on these proteins.