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Recurrent neuroleptic malignant syndrome associated with inv dup(15) and mental retardation
Author(s) -
Lazarus Arthur L.,
Moore Kenneth E.,
Spinner Nancy B.
Publication year - 1991
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1991.tb02987.x
Subject(s) - dup , neuroleptic malignant syndrome , malignant hyperthermia , pharmacogenetics , medicine , adverse effect , pediatrics , psychiatry , genotype , anesthesia , genetics , gene duplication , gene , biology
Neuroleptic malignant syndrome (NMS) is an uncommon but serious adverse reaction to neuroleptic drugs. Clinically, it resembles malignant hyperthermia, a pharmacogenetic disorder of anesthesiology. Inv dup(15) is a rare but underrecognized cause of mental retardation among institutionalized patients. NMS and inv dup(15) have not been previously reported together. Their association should encourage clinicians to search for genetic markers for NMS.