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Association of hypercholesterolemia and apolipoprotein E4 in school children
Author(s) -
Yanagi Hisako,
Shimakura Yae,
Yamanouchi Yasuko,
Watanabe Yuka,
Tsuchiya Shigeru,
Hamaguchi Hideo
Publication year - 1990
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1990.tb03579.x
Subject(s) - apolipoprotein e , apolipoprotein b , medicine , familial hypercholesterolemia , obesity , endocrinology , association (psychology) , cholesterol , psychology , disease , psychotherapist
To investigate the association of apolipoprotein (APO) E4 and hypercholesterolemia in children, we studied the APOE phenotypes of 51 school‐age children with hypercholesterolemia and of 51 age, sex and obesity index‐matched controls with normocholesterolemia by two‐dimensional gel electrophoresis. APOE4 was present in 21 of 51 hypercholesterolemic children (41.2%), and in nine of 51 control subjects (17.6%). The difference was significant (p<0.01). This finding indicates that APOE4 is associated with hypercholesterolemia in children.