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Time trends (1980–1987) of ten selected informative morphogenetic variants in a newborn population
Author(s) -
Merlob P.,
Aitkin I.
Publication year - 1990
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1990.tb03544.x
Subject(s) - logistic regression , population , hypertelorism , statistical significance , medicine , biology , demography , anatomy , environmental health , sociology
The annual prevalence rates of ten selected informative morphogenetic variants (IMVs) were studied in 31 194 newborn infants over a period of 8 years (1980–1987). Two of them (preauricular sinus and ocular hypertelorism) revealed a highly significant decrease by logistic regression analysis. The other eight presented a stable pattern or small fluctuations which did not reach statistical significance. These data may serve as valuable baseline rates for monitoring IMVs in a specific newborn population. Their potential informative value as indicators of altered morphogenesis and their power for monitoring programs of environmental teratogenicity should be carefully verified.