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The common fragile site in band q27 of the human X chromosome is not coincident with the fragile X
Author(s) -
Sutherland Grant R.,
Baker Elizabeth
Publication year - 1990
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1990.tb03498.x
Subject(s) - chromosomal fragile site , fragile x syndrome , fragile x , genetics , cytogenetics , biology , chromosome , long arm , x chromosome , high resolution , gene , geography , remote sensing
The common fragile site on the end of the long arm of the human X chromosome has been shown to be at a different location from the rare fragile site which produces the fragile X syndrome of intellectual handicap. The different locations can be clearly seen in chromosomes at about the 550 band level of resolution. This finding should help resolve difficulties in fragile X cytogenetics where expression of the common fragile site can lead to false positive diagnoses.