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Multipoint linkage mapping of the Xq25‐q26 region in a family affected by the X‐linked lymphoproliferative syndrome
Author(s) -
Sylla Bakary S.,
Wang Qing,
Hayoz Daniel,
Lathrop G. Mark,
Lenoir Gilbert M.
Publication year - 1989
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1989.tb03377.x
Subject(s) - locus (genetics) , genetic linkage , genetics , genetic marker , gene mapping , biology , gene , microbiology and biotechnology , chromosome
We have performed, in a large Swiss family, a study of linkage between various DNA markers in the Xq24–27 region and the locus for the X‐linked lymphoproliferative syndrome (XLP). Our results indicated that the marker DXS37 in Xq25‐q26 is genetically linked to the XLP syndrome. The multipoint linkage analysis showed that the disease locus is distal to DXS11, but proximal to the hypoxanthine phosphoribosyl‐transferase gene (HPRT).