Premium
The contribution of H LA to rheumatoid arthritis
Author(s) -
Deighton C. M.,
Walker D. J.,
Griffiths I. D.,
Roberts D. F.
Publication year - 1989
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1989.tb03185.x
Subject(s) - concordance , rheumatoid arthritis , haplotype , sibling , population , medicine , genetics , gene , biology , immunology , psychology , developmental psychology , environmental health , genotype
The contribution of genes within the major histocompatability complex to rheumatoid arthritis has been calculated (Rotter & Landaw 1984). Separate data from hospital‐ and population‐based studies of monozygotic twin concordance rates and sibling recurrence risks have been used, along with material from published haplotype‐sharing studies. Using either source of information gives the same result, a contribution of 37%.