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Interaction between low density lipoprotein receptor (LDLR) and apolipoprotein E (apoE) alleles contributes to normal variation in lipid level
Author(s) -
Pedersen Jan Chr.,
Berg Kåre
Publication year - 1989
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1989.tb02953.x
Subject(s) - apolipoprotein e , ldl receptor , allele , apolipoprotein b , medicine , endocrinology , lipoprotein , gene isoform , apolipoprotein c2 , genotype , receptor , cholesterol , biology , population , genetics , locus (genetics) , low density lipoprotein , very low density lipoprotein , gene , disease , environmental health
Subjects drawn from a population‐based register were studied with respect to lipid level association. The association of isoforms of apolipoprotein E (apoE) with lipid level in the general population was found to be limited to people with one particular genotype at the low density lipoprotein receptor (LDLR) locus. The results presented in this paper suggest that functional LDLR variants enhance or limit the effect of isoforms of apoE. The association between apoE4 and serum total and LDL cholesterol level may be mediated through the LDL (apoB100, apoE) receptor to a greater extent than previously thought.