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Genetic linkage between Huntington's disease and D4S10(G8) in Scottish families
Author(s) -
Holloway Susan,
Millan F. A.,
Curtis Ann,
Mennie Moira,
Brock D. J. H.
Publication year - 1989
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1989.tb02918.x
Subject(s) - recombination fraction , genetics , locus (genetics) , huntington's disease , genetic linkage , lod score , genetic marker , confidence interval , biology , linkage (software) , disease , medicine , gene mapping , gene , chromosome
Genetic linkage between Huntington's disease (HD) and polymorphic DNA markers at the D4S10 locus has been investigated in 16 Scottish families. A maximum lod score of 3.499 at a recombination fraction of 0.07 was found, with 95% confidence limits of 0.02 and 0.22. Only one obvious recombinant was detected, and the wide confidence limits probably reflect the large number of unaffected individuals whose risk could only be estimated empirically.