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Selective immunodeficiency with defect in interferon‐gamma induction in two sibs with recurrent infections
Author(s) -
Tzoneva Maria,
Ganev Varban,
Galabov Angel,
Georgieva Kitchka
Publication year - 1988
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1988.tb03480.x
Subject(s) - phytohaemagglutinin , interferon , immunology , interferon gamma , medicine , virology , stimulation , biology , lymphocyte , cytokine
Phytohaemagglutinin induces interferon‐gamma synthesis in lymphocyte cultures from healthy individuals. We report two sibs with recurrent infections, selective IgA deficiency, and reduced blast transformation index under PHA‐stimulation, without interferon‐gamma response.