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A linkage study of the locus for X‐linked Charcot‐Marie‐Tooth disease
Author(s) -
Goonewardena P.,
Welihinda J.,
Anvret M.,
Gyftodimou J.,
Haegermark A.,
Iselius L.,
Lindsten J.,
Pettersson U.
Publication year - 1988
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1988.tb03477.x
Subject(s) - locus (genetics) , genetics , biology , genetic linkage , gene
A large family with Charcot‐Marie‐Tooth disease, showing a probable X‐linked incomplete dominant inheritance, was studied by linkage analysis. Results, obtained by the use of X chromosome specific DNA probes of known regional location, suggest that the disease locus is linked to the DXYS1 locus (ž=2.59 at θ= 0.00) and to the DXS14 locus and, places the disease locus between the DXYS1 locus and the DXS14 locus, near the centromere of the X chromosome. Together with the published data, a distance of 13 cM (ž= 6.95) was assessed between the disease locus and the DXYS1 locus.