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HLA determinants in 70 Danish patients with idiopathic haemochromatosis
Author(s) -
Milman Nils,
Graudal Niels,
Nielsen Lillian Staub,
Fenger Kirsten
Publication year - 1988
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1988.tb03450.x
Subject(s) - relative risk , human leukocyte antigen , danish , medicine , gastroenterology , antigen , immunology , confidence interval , linguistics , philosophy
HLA‐A, ‐B, ‐C and ‐DR antigens were determined in 70 unrelated Danish patients with idiopathic haemochromatosis. The frequencies of HLA‐A and ‐B antigens compared to 1967 normal control subjects and the relative risk values (RR) were: A3 , 80.0% vs. 26.9% (P<0.0001), RR=10.9; B7 , 60.0% vs. 26.8% (P<0.0001), RR=4.1; B14 , 10.0% vs. 4.5% (P=0.03), RR=2.4; B47 , 4.3% vs. 0.5% (P<0.0001), RR=9.7; A3, B7 , 51.4% vs. 12.2% (P<0.0001), RR=7.6; A3, B14 , 10.0% vs. 1.4% (P<0.0001), RR=7.7; A3, B47 , 4.3% vs. 0.5% (P<0.0001), RR=9.7. Six patients (8.6%) possessed none of these four typical antigens. There was no association between disease and the frequencies of HLA‐C and HLA‐DR antigens. The pattern of HLA‐antigens associated with haemochromatosis in Denmark shows similarities to those reported both in Germany, being HLA‐A3, B7 dominated, and in Brittany, Great Britain and Central Sweden, being HLA‐A3, B14 dominated.