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Translocation t(13;14) in nine generations with a case of translocation homozygosity
Author(s) -
Eklund A.,
Simola K. O. J.,
Ryynänen M.
Publication year - 1988
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1988.tb03415.x
Subject(s) - chromosomal translocation , robertsonian translocation , offspring , trisomy , biology , genetics , karyotype , chromosome , pregnancy , gene
The Robertsonian translocation t(13;14) (p11;q11) was studied in three families with probable common ancestry in Eastern Finland. In the largest family the translocation has segregated through at least nine generations. The same family also included a female who was homozygous for t(13;14). No clear‐cut effect of the translocation on fertility could be demonstrated and only one case of trisomy 13 was recorded in the offspring of t(13;14) carriers. The results are discussed, with implications for human chromosomal evolution.